| 세션명 | 의료용 고분자 부문위원회 (I) |
|---|---|
| 발표장 | 제2회장 |
| 논문코드 | 1L2-8 |
| 발표일 | 2021-10-21 |
| 발표시간 | 17:15-17:40 |
| 논문제목 | A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification |
| 발표자 | 김환 |
| 발표자 소속 | 한국교통대학교 |
| 저자 | 김환† |
| 소속 | 한국교통대학교 |
| 논문초록 | Recent developmental engineering efforts aim to recapitulate endochondral ossification, a critical step in bone formation. However, this process entails the condensation of mesenchymal stem cells into cartilaginous templates, which requires long-term cultures and is challenging to scale up. Here, a biomimetic scaffold is developed that allows rapid and self-sustained EO without initial hypertrophic chondrogenesis. This composite scaffold enables human endothelial cells and MSCs to rapidly assemble into osteovascular niches in immunodeficient mice. These niches contain ECFC-lined blood vessels and perivascular MSCs that differentiate into pre-osteoblasts after one week in vivo. Subsequently, multiple ossification centers are formed, leading to de novo bone tissue formation, including mature human osteoblasts, collagen-rich mineralized extracellular matrix, hydroxyapatite, and gradual mechanical competence. The findings suggest a novel bioengineering approach to recapitulate EO. |
THE POLYMER SOCIETY OF KOREA